Nevertheless, little is still known about the influence of carbohydrates on the toxicity and cellular uptake of nanoparticles.
Ag-NPs functionalized with three different monosaccharides and ethylene glycol were synthesized and characterised.
Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases.
Nanoparticles that are internalized by cells are not exported from cells but are split between daughter cells when the parent cell divides.
Nanotherapeutics commonly utilizes small-molecule drugs, peptides, proteins, and nucleic acids loaded in nano-scale carriers such as nanoparticle (NP) made of organic polymers, inorganic particles, biological lipids, and so on.
NPs are uptaken into a cell known as endocytosis procedure, while free drugs typically pass through the membrane unless they are kicked out of the cell by efflux pump mechanism.
Carbohydrate coating on silver nanoparticles modulates both oxidative stress and cellular uptake, but mainly the first has an impact on toxicity.
These findings provide new perspectives on modulating the bioactivity of Ag-NPs by using carbohydrates. Silver nanoparticles (Ag-NPs) in particular, show excellent anti-microbial properties and therefore are rapidly being incorporated into a wide array of consumer products such as textiles, cosmetics or packaging materials, increasing the likelihood of human and environmental exposure .