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In addition, perturbation of Ap2a2 results in altered lipid droplet formation and impaired triacylgylceride storage.

We are currently investigating the oxidative phosphorylation, anaerobic glycolysis and fatty acid metabolic effects in the context of altered Ap2a2 expression. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail.

To start: 1st October 2017 Award 1 fully funded Io PPN/MNDA Ph D studentship Project Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder.

The underlying genetic architecture of the disorder is broad and exome sequencing of familial ALS samples (found in approximately 10% of total cases) has successfully identified six new ALS genes over the last five years eg. Our group has recently identified another novel ALS gene, ANXA11 (recently published in Sci Transl Med. Annexin A11 (encoded by ANXA11) is a phospholipid and calcium binding protein, in which ALS mutations form insoluble aggregates in-vitro and in post-mortem tissue that also abolish binding to calcyclin.

The student will acquire cutting-edge biochemistry, cell culture and molecular biology techniques and use start-of-the-art microscopy equipment and actively interrogate ALS genes using Zebrafish models.

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Ap2a2 is a component of the Adaptor protein 2 complex that functions in clathrin-dependent endocytosis of receptors and nutrient cargo.

requirement have the highest proliferative potency. Self-renewal via asymmetrical cell division (ACD) is vital for maintenance of HSC numbers and perturbation of this process can lead to an impaired hematopoietic system, with subsequent blood diseases such as acute leukemia and/or bone marrow failure.

How and which HSCs are programmed for ACD remain central and unanswered questions.

However, a simple qualitative picture of how this occupation controls the magnetocrystalline anisotropy (MCA) and even why in certain cases the MCA has opposite sign still remains elusive.

In this paper, we exploit a simple model of orbital populations to elucidate a number of features typical for the interface MCA and the effect of electric field on it, for 3d transition metal thin films used in magnetic tunnel junctions.

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